USG-guided biopsy is a minimally invasive procedure that uses real-time ultrasound imaging to accurately locate abnormal tissue. A fine or core needle is inserted through a small puncture to obtain a precise tissue sample. The continuous ultrasound guidance improves accuracy and reduces complications. It requires no major incision and is performed under local anesthesia for maximum comfort. The procedure is quick, safe, done as a day-care service, and helps in early and accurate diagnosis.